منابع مشابه
Clinical and prognostic role of annexin A2 in multiple myeloma.
Annexin A2 (ANXA2) promotes myeloma cell growth, reduces apoptosis in myeloma cell lines, and increases osteoclast formation. ANXA2 has been described in small cohorts of samples as expressed by myeloma cells and cells of the BM microenvironment. To investigate its clinical role, we assessed 1148 samples including independent cohorts of 332 and 701 CD138-purified myeloma cell samples from previ...
متن کاملClinical and Pathological Features of Iraqi Patients with Prostate Cancer
Background: The clinical pathological features were detected by measuring the prostatic acid phosphatase (PAP) activity according to the stages and grades of prostate cancer. We also explored the relationship between the disease and age with family history among the patients. Methods: Data were collected from direct interview and from the patient’s records. Blood samples that collected before ...
متن کاملAnnexin A2 expression during cellular differentiation in myeloid cell lines.
Annexin A2 is a calcium-dependent, phospholipid-binding protein found on many cell types. It consists of a short hydrophobic tail (Ser(2)-Asn(32)), which dictates its function, and a core domain (Phe(33)-Asp(339)), which is involved in phospholipid binding. Annexin A2 has been implicated in a number of biochemical processes, including cell proliferation, foetal immune tolerance, ion-channel act...
متن کامل[Annexin A2 expression in head and neck squamous cell carcinoma].
OBJECTIVE Over-expression of annexin A2 (ANXA2) has been reported in various cancers. However, no data are available on the expression of this protein in head and neck squamous cell carcinomas (HNSCC). The objective of this preliminary study is to investigate the expression of ANXA2 in these carcinomas. MATERIAL AND METHOD ANXA2 expression was analyzed by immunohistochemistry in paraffin-embe...
متن کاملStromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is renowned for high rates of metastasis and poor survival. Its notoriously dense fibrotic stroma contributes to chemoresistance. Stromal signaling in PDA is recognized for its multiple roles in regulating tumor invasion and metastasis. However, no stromal biomarker which can predict survival in PDA exists. Annexin A2 (AnxA2) was formerly identified as a m...
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ژورنال
عنوان ژورنال: Pathology
سال: 2021
ISSN: 0031-3025
DOI: 10.1016/j.pathol.2020.07.006